{"product_id":"nosocomial-pneumonia-pipeline-insight-2023","title":"Nosocomial Pneumonia- Pipeline Insight, 2023","description":"\u003cp\u003eNosocomial Pneumonia- Pipeline Insight, 2023\u003c\/p\u003e\n\n\u003cp\u003eDelveInsight’s, “Nosocomial Pneumonia- Pipeline Insight, 2023” report provides comprehensive insights about 13+ companies and 13+ pipeline drugs in Nosocomial Pneumonia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.\u003c\/p\u003e\n\n\u003cp\u003eGeography Covered\u003c\/p\u003e\n\n\u003cp\u003eGlobal coverage\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia: Understanding\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia: Overview\u003c\/p\u003e\n\n\u003cp\u003eNosocomial pneumonia or hospital-acquired pneumonia (HAP) is defined as pneumonia that occurs 48 hours or more after hospital admission and not incubating at the admission time. HAP occurs at a rate of 5 to 10 per 1000 hospital admissions and is considered the most common cause of hospital-acquired infection in Europe and the United States. Over 90% of pneumonia episodes developing in ICUs occur in patients who are intubated and mechanically ventilated. Establishing the diagnosis of HAP remains controversial, and there is no superior method. In the guidelines for the management of HAP and VAP by Infectious Diseases Society of America\/American Thoracic Society 2016, diagnosis is based upon a presence of new lung infiltrate and clinical evidence that the infiltrate is of an infectious cause (new onset of fever, purulent sputum, leukocytosis, and a decline in oxygenation). Clinical pulmonary infection score (CPIS), which includes clinical and radiological criteria, is suggested to increase the likelihood of the presence of pneumonia, but some investigators suggest that the CPIS while being sensitive, lacks specificity and leads to unnecessary antimicrobial treatment. Symptoms may include cough, expectoration, and a rise in body temperature, chest pain or dyspnea. Signs include fever, tachypnea, consolidations or crackles. For patients with HAP who have a risk factor for MRSA infection, specifically those with prior intravenous antibiotic use within 90 days, hospitalization in a unit where greater than 20% of S. aureus isolates are methicillin resistant, or the prevalence of MRSA is not known, or who are at high risk for mortality, prescribe an antibiotic active against MRSA like vancomycin or linezolid is recommended (weak recommendation, very low-quality evidence). Risk factors for mortality include the need for ventilator support due to HAP and septic shock. All patients with HAP or VAP should be reevaluated for clinical response and the microbiologic results after initial empiric antimicrobial therapy. Many studies have found that HAP is associated with an increased risk of death.\u003c\/p\u003e   \n\n\u003cp\u003e\"\"Nosocomial Pneumonia- Pipeline Insight, 2023\"\" report by DelveInsight outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Nosocomial Pneumonia pipeline landscape is provided which includes the disease overview and Nosocomial Pneumonia treatment guidelines. The assessment part of the report embraces, in depth Nosocomial Pneumonia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Nosocomial Pneumonia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.\u003c\/p\u003e\n\n\u003cp\u003eReport Highlights\u003c\/p\u003e\n\n\u003cp\u003eThe companies and academics are working to assess challenges and seek opportunities that could influence Nosocomial Pneumonia R\u0026amp;D. The therapies under development are focused on novel approaches to treat\/improve Nosocomial Pneumonia.\u003c\/p\u003e \n\n\u003cp\u003eNosocomial Pneumonia Emerging Drugs Chapters\u003c\/p\u003e\n\n\u003cp\u003eThis segment of the Nosocomial Pneumonia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia Emerging Drugs\u003c\/p\u003e\n\n\u003cp\u003eTosatoxumab: Aridis Pharmaceuticals\u003c\/p\u003e\n\n\u003cp\u003eTosatoxumab (AR-301, Salvecin) is an intravenous, broadly active, human monoclonal antibody (IgG1?) that targets the Staphylococcus aureus alpha-toxin or the S. aureus alpha-hemolysin. The drug is in Phase III clinical developmental studies for the treatment of Nosocomial Pneumonia.\u003c\/p\u003e\n\n\u003cp\u003eSuvratoxumab: AstraZeneca\u003c\/p\u003e \n\n\u003cp\u003eSuvratoxumab is a human immunoglobulin G1 kappa monoclonal antibody with an extended half-life, targeted pore-forming ? toxin of Staphylococcus aureus. The drug is in Phase II clinical studies for the treatment of Nosocomial Pneumonia.\u003c\/p\u003e\n\n\u003cp\u003eRifabutin: BioVersys\u003c\/p\u003e\n\n\u003cp\u003eRifabutin (BV100) has a novel mode of action addressing carbapenem resistant Acinetobacter baumannii (CRAB) lung and blood stream infections. Currently the drug is in Phase I of stage of development for the treatment of Nosocomial Pneumonia.\u003c\/p\u003e\n\n\u003cp\u003eCMTX 101 : Clarametyx Biosciences\u003c\/p\u003e\n\n\u003cp\u003eClarametyx’s pioneering therapy, CMTX-101, is a monoclonal antibody designed to rapidly collapse bacterial biofilms – protective shields that coat bacterial pathogens and help make them resistant to the effects of antibiotics and immune response.  CMTX-101 targets a region of DNABII binding proteins that are essentially identical across all pathogenic bacteria. Bacterial DNABII proteins stabilize and maintain the integrity of bacterial biofilms. Precisely targeting this region on the DNABII proteins rapidly collapses biofilms, rendering the bacteria more vulnerable to the effects of antibiotics and the immune system. Currently, the drug is in Pre-Clinical stage of development for the treatment of nosocomial pneumonia.\u003c\/p\u003e \n\n\u003cp\u003eFurther product details are provided in the report……..\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia: Therapeutic Assessment\u003c\/p\u003e\n\n\u003cp\u003eThis segment of the report provides insights about the different Nosocomial Pneumonia drugs segregated based on following parameters that define the scope of the report, such as:\u003c\/p\u003e\n\n\u003cp\u003eMajor  Players in Nosocomial Pneumonia\u003c\/p\u003e\n\n\u003cp\u003eThere are approx. 13+ key companies which are developing the therapies for Nosocomial Pneumonia. The companies which have their Nosocomial Pneumonia drug candidates in the most advanced stage, i.e. phase III include, Aridis Pharmaceuticals.\u003c\/p\u003e\n\n\u003cp\u003ePhases\u003c\/p\u003e\n\n\u003cp\u003eDelveInsight’s report covers around 13+ products under different phases of clinical development like\u003c\/p\u003e\n\n\u003cp\u003eLate stage products (Phase III)\u003c\/p\u003e\n\n\u003cp\u003eMid-stage products (Phase II)\u003c\/p\u003e\n\n\u003cp\u003eEarly-stage product (Phase I) along with the details of\u003c\/p\u003e \n\n\u003cp\u003ePre-clinical and Discovery stage candidates\u003c\/p\u003e\n\n\u003cp\u003eDiscontinued \u0026amp; Inactive candidates\u003c\/p\u003e\n\n\u003cp\u003eRoute of Administration\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as\u003c\/p\u003e \n\n\u003cp\u003eIntravenous\u003c\/p\u003e\n\n\u003cp\u003eSubcutaneous\u003c\/p\u003e\n\n\u003cp\u003eOral\u003c\/p\u003e\n\n\u003cp\u003eIntramuscular\u003c\/p\u003e\n\n\u003cp\u003eMolecule Type\u003c\/p\u003e\n\n\u003cp\u003eProducts have been categorized under various Molecule types such as\u003c\/p\u003e\n\n\u003cp\u003eMonoclonal antibody\u003c\/p\u003e\n\n\u003cp\u003eSmall molecule\u003c\/p\u003e\n\n\u003cp\u003ePeptide\u003c\/p\u003e\n\n\u003cp\u003eProduct Type\u003c\/p\u003e\n\n\u003cp\u003eDrugs have been categorized under various product types like Mono, Combination and Mono\/Combination.\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia: Pipeline Development Activities\u003c\/p\u003e \n\n\u003cp\u003eThe report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Nosocomial Pneumonia therapeutic drugs key players involved in developing key drugs.\u003c\/p\u003e \n\n\u003cp\u003ePipeline Development Activities\u003c\/p\u003e\n\n\u003cp\u003eThe report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Nosocomial Pneumonia drugs.\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia Report Insights\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia Pipeline Analysis\u003c\/p\u003e\n\n\u003cp\u003eTherapeutic Assessment\u003c\/p\u003e\n\n\u003cp\u003eUnmet Needs\u003c\/p\u003e\n\n\u003cp\u003eImpact of Drugs\u003c\/p\u003e\n\n\u003cp\u003eNosocomial Pneumonia Report Assessment\u003c\/p\u003e\n\n\u003cp\u003ePipeline Product Profiles\u003c\/p\u003e\n\n\u003cp\u003eTherapeutic Assessment\u003c\/p\u003e\n\n\u003cp\u003ePipeline Assessment\u003c\/p\u003e\n\n\u003cp\u003eInactive drugs assessment\u003c\/p\u003e\n\n\u003cp\u003eUnmet Needs\u003c\/p\u003e\n\n\u003cp\u003eKey Questions\u003c\/p\u003e\n\n\u003cp\u003eCurrent Treatment Scenario and Emerging Therapies:\u003c\/p\u003e\n\n\u003cp\u003eHow many companies are developing Nosocomial Pneumonia drugs?\u003c\/p\u003e\n\n\u003cp\u003eHow many Nosocomial Pneumonia drugs are developed by each company?\u003c\/p\u003e\n\n\u003cp\u003eHow many emerging drugs are in mid-stage, and late-stage of development for the treatment of Nosocomial Pneumonia?\u003c\/p\u003e\n\n\u003cp\u003eWhat are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Nosocomial Pneumonia therapeutics?\u003c\/p\u003e \n\n\u003cp\u003eWhat are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?\u003c\/p\u003e \n\n\u003cp\u003eWhat are the clinical studies going on for Nosocomial Pneumonia and their status?\u003c\/p\u003e\n\n\u003cp\u003eWhat are the key designations that have been granted to the emerging drugs?\u003c\/p\u003e\n\n\u003cp\u003eKey Players\u003c\/p\u003e\n\n\u003cp\u003eAridis Pharmaceuticals\u003c\/p\u003e\n\n\u003cp\u003eAstraZeneca\u003c\/p\u003e\n\n\u003cp\u003eBioVersys\u003c\/p\u003e\n\n\u003cp\u003eClarametyx Biosciences\u003c\/p\u003e\n\n\u003cp\u003eKey Products\u003c\/p\u003e\n\n\u003cp\u003eSuvratoxumab\u003c\/p\u003e\n\n\u003cp\u003eTosatoxumab\u003c\/p\u003e\n\n\u003cp\u003eRifabutin\u003c\/p\u003e\n\n\u003cp\u003eCMTX 101\u003c\/p\u003e","brand":"Life Science","offers":[{"title":"May, 2023 \/ 60 Pages \/ MCW16236567","offer_id":47652199137586,"sku":null,"price":1800.0,"currency_code":"USD","in_stock":true}],"url":"https:\/\/www.hardmanwell.com\/products\/nosocomial-pneumonia-pipeline-insight-2023","provider":"HARDMAN AND WELL MANAGEMENT CONSULTANCIES L.L.C","version":"1.0","type":"link"}